Journal article
Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction
Current opinion in neurobiology, v 82, 102763
01 Oct 2023
PMID: 37611531
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Locomotion is a complex motor task executed by spinal neurons. Given the diversity of spinal cord neurons, linking neuronal cell type to function is a challenge. Molecular identification of broad spinal interneuronal classes provided a great advance. Recent studies have used other classifiers, including location, electrophysiological properties, and connectivity, in addition to gene profiling, to narrow the acuity with which groups of neurons can be related to specific functions. However, there are also functional populations without a clear identifier, as exemplified by rhythm generating neurons. Other considerations, including experience or plasticity, add a layer of complexity to the definition of functional subpopulations of spinal neurons, but spinal cord injury may provide insight.
•Many ways are used to classify subpopulations of locomotor interneurons.•Subdivisions of populations are interrelated, suggesting a common framework.•Rhythm-generating neurons are medially located but an identifier remains elusive.•Spinal cord injury (SCI) may reveal the impact of experience and extrinsic input on neuronal identity.
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Details
- Title
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction
- Creators
- Kimberly J. Dougherty - Drexel University, Neurobiology and Anatomy
- Publication Details
- Current opinion in neurobiology, v 82, 102763
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Drexel University
- Web of Science ID
- WOS:001066028300001
- Scopus ID
- 2-s2.0-85168522001
- Other Identifier
- 991021861278604721
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- Web of Science research areas
- Neurosciences