Logo image
Back
Distribution of Duffy Phenotypes among Plasmodium vivax Infections in Sudan
Journal article   Open access   Peer reviewed

Distribution of Duffy Phenotypes among Plasmodium vivax Infections in Sudan

Musab M A Albsheer, Kareen Pestana, Safaa Ahmed, Mohammed Elfaki, Eiman Gamil, Salma M Ahmed, Muntaser E Ibrahim, Ahmed M Musa, Eugenia Lo and Muzamil M Abdel Hamid
Genes, v 10(6), 437
08 Jun 2019
DOI: https://doi.org/10.3390/genes10060437
PMID: 31181786
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3390/genes10060437View
Published, Version of Record (VoR) Open

Abstract

Adult Duffy Blood-Group System - blood Erythrocytes - parasitology Female Humans Malaria, Falciparum - blood Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Malaria, Vivax - blood Malaria, Vivax - epidemiology Malaria, Vivax - parasitology Male Parasitemia - blood Parasitemia - epidemiology Parasitemia - parasitology Plasmodium falciparum - pathogenicity Plasmodium vivax - genetics Plasmodium vivax - pathogenicity Sudan - epidemiology Malaria Phenotype
Negative Duffy expression on the surface of human red blood cells was believed to be a barrier for Plasmodium vivax infection in most Africans. However, P. vivax has been demonstrated to infect Duffy-negative individuals in several Central and East African countries. In this study, we investigated the distribution of Duffy blood group phenotypes with regard to P. vivax infection and parasitemia in Sudan. Out of 992 microscopic-positive malaria samples, 190 were identified as P. vivax positive infections. Among them, 186 were P. vivax mono-infections and 4 were mixed P. vivax and Plasmodium falciparum infections. A subset of 77 samples was estimated with parasitemia by quantitative real-time PCR. Duffy codons were sequenced from the 190 P. vivax positive samples. We found that the Duffy Fy(a-b+) phenotype was the most prevalent, accounting for 67.9% of all P. vivax infections, while homozygous Duffy-negative Fy(a-b-) accounted for 17.9% of the P. vivax infections. The prevalence of infection in Fy(a-b+) and Fy(a+b-)were significantly higher than Fy(a-b-) phenotypes (p = 0.01 and p < 0.01, respectively). A significantly low proportion of P. vivax infection was observed in Duffy negative individuals Fy(a-b-). This study highlights the prevalence of P. vivax in Duffy-negatives in Sudan and indicates low parasitemia among the Duffy-negative individuals.

Metrics

1 Record Views
20 citations in Web of Science

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: SDGs in the Output

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Genetics & Heredity
Logo image