Journal article
Diurnal Salivary Cortisol Is Associated with Body Mass Index and Waist Circumference: The Multiethnic Study of Atherosclerosis
Obesity (Silver Spring, Md.), v 21(1), pp E56-E63
01 Jan 2013
PMID: 23404865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Neuroendocrine abnormalities, such as activation of the hypothalamic-pituitary-adrenal (HPA) axis, are associated with obesity; however, few large-scale population-based studies have examined HPA axis and markers of obesity. We examined the cross-sectional association of the cortisol awakening response (CAR) and diurnal salivary cortisol curve with obesity.
Design and Methods: The Multiethnic Study of Atherosclerosis Stress Study includes 1,002 White, Hispanic, and Black men and women (mean age 65 +/- 9.8 years) who collected up to 18 salivary cortisol samples over 3 days. Cortisol profiles were modeled using regression spline models that incorporated random parameters for subject-specific effects. Cortisol curve measures included awakening cortisol, CAR (awakening to 30-min postawakening), early decline (30 min to 2-h postawakening), late decline (2-h postawakening to bedtime), and the corresponding areas under the curve (AUC). Body mass index (BMI) and waist circumference (WC) were used to estimate adiposity.
Results: For the entire cohort, both BMI and WC were negatively correlated with awakening cortisol (P < 0.05), AUC during awakening rise, and early decline and positively correlated to the early decline slope (P < 0.05) after adjustments for age, race/ethnicity, gender, diabetes status, socioeconomic status, beta-blockers, steroids, hormone replacement therapy, and smoking status. No heterogeneities of effects were observed by gender, age, and race/ethnicity.
Conclusions: Higher BMI and WC are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates.
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Details
- Title
- Diurnal Salivary Cortisol Is Associated with Body Mass Index and Waist Circumference: The Multiethnic Study of Atherosclerosis
- Creators
- Shivam Champaneri - Johns Hopkins MedicineXiaoqiang Xu - Johns Hopkins MedicineMercedes R. Carnethon - Northwestern UniversityAlain G. Bertoni - Wake Forest UniversityTeresa Seeman - University of California, Los AngelesAmy S. DeSantis - University of MichiganAna Diez Roux - Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USASandi Shrager - University of WashingtonSherita Hill Golden - Bloomberg (United States)
- Publication Details
- Obesity (Silver Spring, Md.), v 21(1), pp E56-E63
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) M01RR000052 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) F32HL010161 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32DK062707 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) N01HC095160 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000322086900008
- Scopus ID
- 2-s2.0-84876222145
- Other Identifier
- 991020111934104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics