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Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice
Journal article   Peer reviewed

Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice

Rodrigo A. España, Craig W. Berridge and Stephen C. Gammie
Peptides (New York, N.Y. : 1980), v 25(11), pp 1927-1934
2004
PMID: 15501524

Abstract

Arousal Locus coeruleus Medial preoptic area Orexin
The hypocretins modulate arousal via actions across multiple terminal fields. Thus, alterations in hypocretin neurotransmission may contribute to altered sleep patterns observed during lactation. This study examined whether lactation is associated with alterations in the number of hypocretin neurons and in diurnal Fos-immunoreactivity within hypocretin neurons in female mice. Alterations in Fos-immunoreactivity were also examined within two hypocretin terminal regions; the medial preoptic area and the locus coeruleus. Fos-immunoreactivity was increased within hypocretin neurons and the medial preoptic area in lactating females. No differences were observed in the number of hypocretin neurons or in Fos-immunoreactivity within the locus coeruleus.

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Web of Science research areas
Biochemistry & Molecular Biology
Endocrinology & Metabolism
Pharmacology & Pharmacy
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