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Journal article
Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis
Metabolism, clinical and experimental, v 61(7), pp 986-995
01 Jul 2012
PMID: 22209664
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (beta = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (beta = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (beta = 2.62; 95% CI, 0.72 to 4.51) (P = .02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P < .05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes. (c) 2012 Elsevier Inc. All rights reserved.
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- Title
- Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis
- Creators
- Shivam Champaneri - Bloomberg (United States)Xiaoqiang Xu - Bloomberg (United States)Mercedes R. Carnethon - Northwestern UniversityAlain G. Bertoni - Wake Forest UniversityTeresa Seeman - University of California, Los AngelesAna Diez Roux - Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USASherita Hill Golden - Johns Hopkins University School of Medicine
- Publication Details
- Metabolism, clinical and experimental, v 61(7), pp 986-995
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- 5 K23 DK071565 / National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R44HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) NO1-HC-95159; NO1-HC-95160; NO1-HC-95161; NO1-HC-95162; NO1-HC-95163; NO1-HC-95164; NO1-HC-95165; NO1-HC-95169 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32 / Ruth L. Kirschstein National Research Service; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000305371700011
- Scopus ID
- 2-s2.0-84862123233
- Other Identifier
- 991020111951304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism