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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Divergent projections of catecholaminergic neurons in the nucleus of the solitary tract to limbic forebrain and medullary autonomic brain regions
Brain research, v 1117(1), pp 69-79
30 Oct 2006
PMID: 16962080
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The nucleus of the solitary tract (NTS) is a critical structure involved in coordinating autonomic and visceral activities. Previous independent studies have demonstrated efferent projections from the NTS to the nucleus paragigantocellularis (PGi) and the central nucleus of the amygdala (CNA) in rat brain. To further characterize the neural circuitry originating from the NTS with postsynaptic targets in the amygdala and medullary autonomic targets, distinct green or red fluorescent latex microspheres were injected into the PGi and the CNA, respectively, of the same rat. Thirty-micron thick tissue sections through the lower brainstem and forebrain were collected. Every fourth section through the NTS region was processed for immunocytochemical detection of tyrosine hydroxylase (TH), a marker of catecholaminergic neurons. Retrogradely labeled neurons from the PGi or CNA were distributed throughout the rostro-caudal segments of the NTS. However, the majority of neurons containing both retrograde tracers were distributed within the caudal third of the NTS. Cell counts revealed that approximately 27% of neurons projecting to the CNA in the NTS sent collateralized projections to the PGi while approximately 16% of neurons projecting to the PGi sent collateralized projections to the CNA. Interestingly, more than half of the PGi and CNA-projecting neurons in the NTS expressed TH immunoreactivity. These data indicate that catecholaminergic neurons in the NTS are poised to simultaneously coordinate activities in limbic and medullary autonomic brain regions.
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Details
- Title
- Divergent projections of catecholaminergic neurons in the nucleus of the solitary tract to limbic forebrain and medullary autonomic brain regions
- Creators
- Beverly A S Reyes - Thomas Jefferson UniversityElisabeth J Van Bockstaele - Thomas Jefferson University
- Publication Details
- Brain research, v 1117(1), pp 69-79
- Publisher
- Elsevier
- Grant note
- K02 DA015395 / NIDA NIH HHS R01 DA009082 / NIDA NIH HHS DA 15395 / NIDA NIH HHS DA 09082 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000242147200008
- Scopus ID
- 2-s2.0-33750016887
- Other Identifier
- 991021903299204721
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- Web of Science research areas
- Neurosciences