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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Diversity of meso-scale architecture in human and non-human connectomes
Nature communications, v 9(1), pp 346-14
24 Jan 2018
PMID: 29367627
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brain function is reflected in connectome community structure. The dominant view is that communities are assortative and segregated from one another, supporting specialized information processing. However, this view precludes the possibility of non-assortative communities whose complex inter-community interactions could engender a richer functional repertoire. We use weighted stochastic blockmodels to uncover the meso-scale architecture of Drosophila, mouse, rat, macaque, and human connectomes. We find that most communities are assortative, though others form core-periphery and disassortative structures, which better recapitulate observed patterns of functional connectivity and gene co-expression in human and mouse connectomes compared to standard community detection techniques. We define measures for quantifying the diversity of communities in which brain regions participate, showing that this measure is peaked in control and subcortical systems in humans, and that inter-individual differences are correlated with cognitive performance. Our report paints a more diverse portrait of connectome communities and demonstrates their cognitive relevance.
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Details
- Title
- Diversity of meso-scale architecture in human and non-human connectomes
- Creators
- Richard F Betzel - University of PennsylvaniaJohn D Medaglia - Drexel UniversityDanielle S Bassett - University of Pennsylvania
- Publication Details
- Nature communications, v 9(1), pp 346-14
- Publisher
- Springer Nature
- Grant note
- R01 NS099348 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000423155700004
- Scopus ID
- 2-s2.0-85041071636
- Other Identifier
- 991019168499704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences