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Divisive Normalization in Olfactory Population Codes
Journal article   Open access   Peer reviewed

Divisive Normalization in Olfactory Population Codes

Shawn R. Olsen, Vikas Bhandawat and Rachel I. Wilson
Neuron (Cambridge, Mass.), v 66(2), pp 287-299
2010
DOI: https://doi.org/10.1016/j.neuron.2010.04.009
PMID: 20435004
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1093/intimm/dxn026View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open
url
https://doi.org/10.1016/j.neuron.2010.04.009View
Published, Version of Record (VoR) Open

Abstract

SIGNALING SYSBIO SYSNEURO
In many regions of the visual system, the activity of a neuron is normalized by the activity of other neurons in the same region. Here we show that a similar normalization occurs during olfactory processing in the Drosophila antennal lobe. We exploit the orderly anatomy of this circuit to independently manipulate feedforward and lateral input to second-order projection neurons (PNs). Lateral inhibition increases the level of feedforward input needed to drive PNs to saturation, and this normalization scales with the total activity of the olfactory receptor neuron (ORN) population. Increasing total ORN activity also makes PN responses more transient. Strikingly, a model with just two variables (feedforward and total ORN activity) accurately predicts PN odor responses. Finally, we show that discrimination by a linear decoder is facilitated by two complementary transformations: the saturating transformation intrinsic to each processing channel boosts weak signals, while normalization helps equalize responses to different stimuli. [Display omitted] ► Lateral inhibition normalizes ORN input to each glomerular processing channel ► Lateral inhibition scales linearly with total ORN activity ► These phenomena are fit by a model originally developed to describe visual activity ► This model predicts PN responses to novel odors with high accuracy

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334 citations in Web of Science
342 citations in Scopus

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