Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Do Tissues From THA Revision of Highly Crosslinked UHMWPE Liners Contain Wear Debris and Associated Inflammation?
Clinical orthopaedics and related research, v 469(8), pp 2308-2317
01 Aug 2011
PMID: 21136220
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polyethylene wear debris is a major contributor to inflammation and the development of implant loosening, a leading cause of THA revisions. To reduce wear debris, highly crosslinked ultrahigh-molecular-weight polyethylene (UHMWPE) was introduced to improve wear properties of bearing surfaces. As highly crosslinked UHMWPE revision tissues are only now becoming available, it is possible to examine the presence and association of wear debris with inflammation in early implant loosening.
We asked: (1) Does the presence of UHMWPE wear debris in THA revision tissues correlate with innate and/or adaptive immune cell numbers? (2) Does the immune cell response differ between conventional and highly crosslinked UHMWPE cohorts?
We collected tissue samples from revision surgery of nine conventional and nine highly crosslinked UHMWPE liners. Polarized light microscopy was used to determine 0.5- to 2-mu m UHMWPE particle number/mm(2), and immunohistochemistry was performed to determine macrophage, T cell, and neutrophil number/mm(2).
For the conventional cohort, correlations were observed between wear debris and the magnitude of individual patient macrophage (rho = 0.70) and T cell responses (rho = 0.71) and between numbers of macrophages and T cells (rho = 0.77) in periprosthetic tissues. In comparison, the highly crosslinked UHMWPE cohort showed a correlation between wear debris and the magnitude of macrophage responses (rho = 0.57) and between macrophage and T cell numbers (rho = 0.68). Although macrophages and T cells were present in both cohorts, the highly crosslinked UHMWPE cohort had lower numbers, which may be associated with shorter implantation times.
The presence of wear debris and inflammation in highly crosslinked UHMWPE revision tissues may contribute to early implant loosening.
Metrics
Details
- Title
- Do Tissues From THA Revision of Highly Crosslinked UHMWPE Liners Contain Wear Debris and Associated Inflammation?
- Creators
- Ryan M. Baxter - Drexel UniversityTheresa A. Freeman - Thomas Jefferson UniversitySteven M. Kurtz - Exponent (United States)Marla J. Steinbeck - Drexel University
- Publication Details
- Clinical orthopaedics and related research, v 469(8), pp 2308-2317
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- R01AR047904 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) NIH R01 AR47904 / National Institute of Arthritis and Musculoskeletal and Skin Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000292271700023
- Scopus ID
- 2-s2.0-79960946322
- Other Identifier
- 991019167464304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Orthopedics
- Surgery