Journal article
Do air gaps with image-guided vaginal cuff brachytherapy impact failure rates in patients with high-intermediate risk FIGO Stage I endometrial cancer?
Brachytherapy, v 20(3), pp 512-518
May 2021
PMID: 33384254
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aim of this study was to assess the impact of air gaps at the cylinder surface on the rate of vaginal cuff failure (VCF) after image-guided adjuvant vaginal cuff brachytherapy (VCBT) in the treatment of high-intermediate risk (HIR) FIGO (Fédération Internationale de Gynécologie et d'Obstétrique (International Federation of Gynecology and Obstetrics)) Stage I endometrial cancer.
A retrospective review of patients treated with image-guided VCBT from 2009 to 2016 for HIR FIGO Stage I endometrial cancer was performed. Air gaps present at the applicator surface on the first postinsertion CT were contoured. Vaginal cuff failure–free survival (VCFFS) was measured from the first fraction of VCBT to VCF.
A total of 234 patients were identified. Air gaps were present on the first postinsertion CT scan in 82% of patients. The median number of air gaps was 2 (interquartile range [IQR] 1–3), median depth of the largest air gap was 2.7 mm (IQR 2.1–3.4 mm), and the median cumulative volume of air gaps was less than 0.1 cm3 (range < 0.1–0.7 cm3). At a median followup of 56 months (IQR 41–69), 12 patients (5%) experienced VCF, of which 4 had isolated VCF and 8 had synchronous pelvic or distant failure. Five-year VCFFS and isolated VCFFS were 96% (95% confidence interval 93–98%) and 98% (95% confidence interval 96–100%), respectively. On univariate analysis, no factors, including the presence, number, maximum depth, or cumulative volume of air gaps, were predictive for VCFFS.
In this population, VCFFS remained high despite most patients having air gaps present on postinsertion CT scan.
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Details
- Title
- Do air gaps with image-guided vaginal cuff brachytherapy impact failure rates in patients with high-intermediate risk FIGO Stage I endometrial cancer?
- Creators
- Adam H. Richman - UPMC Hillman Cancer CenterAnkur K. Patel - UPMC Hillman Cancer CenterJoshua L. Rodríguez-López - University of Pittsburgh School of MedicineAndrew Keller - UPMC Hillman Cancer CenterJohn A. Vargo - UPMC Hillman Cancer CenterHayeon Kim - UPMC Hillman Cancer CenterPaniti Sukumvanich - Magee-Womens HospitalJessica L. Berger - Magee-Womens HospitalMichelle M. Boisen - Magee-Womens HospitalRobert Edwards - Magee-Womens HospitalSarah E. Taylor - Magee-Womens HospitalMadeleine B. Courtney-Brooks - University of Pittsburgh School of MedicineAlexander Olawaiye - University of PittsburghBrian C. Orr - Magee-Womens HospitalJamie L. Lesnock - Magee-Womens HospitalSushil Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 20(3), pp 512-518
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000651851900001
- Scopus ID
- 2-s2.0-85098513249
- Other Identifier
- 991021897371604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging