Journal article
Do respiratory virus infections modify associations of asthma exacerbation with aeroallergens or fine particulate matter? A time series study in Philadelphia PA
International journal of environmental health research
02 Jan 2024
PMID: 38164931
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Respiratory virus infections are related to over 80% of childhood asthma exacerbations. They enhance pro-inflammatory mediator release, especially for sensitized individuals exposed to pollens/molds. Using a time-series study design, we investigated possible effect modification by respiratory virus infections of the associations between aeroallergens/PM
and asthma exacerbation rates. Outpatient, emergency department (ED), and inpatient visits for asthma exacerbation among children with asthma (28,540/24,444 [warm/cold season]), as well as viral infection counts were obtained from electronic health records of the Children's Hospital of Philadelphia from 2011 to 2016. Rate ratios (RRs, 90th percentile vs. 0) for late-season grass pollen were 1.00 (0.85-1.17), 1.04 (0.95-1.15), and 1.12 (0.96-1.32), respectively, for respiratory syncytial virus (RSV) counts within each tertile. However, similar trends were not observed for weed pollens/molds or PM
. Overall, our study provides little evidence supporting effect modification by respiratory viral infections.
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Details
- Title
- Do respiratory virus infections modify associations of asthma exacerbation with aeroallergens or fine particulate matter? A time series study in Philadelphia PA
- Creators
- Wanyu Huang - Drexel UniversityLeah H Schinasi - Drexel UniversityChén C Kenyon - Children's Hospital of PhiladelphiaAmy H Auchincloss - Drexel UniversityKari Moore - Drexel UniversitySteven Melly - Drexel UniversityLucy F Robinson - Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USAChristopher B Forrest - Children's Hospital of PhiladelphiaAnneclaire J De Roos - Drexel University
- Publication Details
- International journal of environmental health research
- Publisher
- Taylor and Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Environmental and Occupational Health
- Web of Science ID
- WOS:001137900600001
- Scopus ID
- 2-s2.0-85181221876
- Other Identifier
- 991021811642204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health