Journal article
Does Vitamin E–Stabilized Ultrahigh-Molecular-Weight Polyethylene Address Concerns of Cross-Linked Polyethylene in Total Knee Arthroplasty?
The Journal of arthroplasty, v 27(3), pp 461-469
Mar 2012
PMID: 22146382
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Concerns about reduced strength, fatigue resistance, and oxidative stability of highly cross-linked and remelted ultrahigh-molecular-weight polyethylene (UHMWPE) have limited its clinical acceptance for total knee arthroplasty. We hypothesized that a highly cross-linked UHMWPE stabilized with vitamin E would have less oxidation and loss of mechanical properties. We compared the oxidation, in vitro strength, fatigue-crack propagation resistance, and wear of highly cross-linked UHMWPE doped with vitamin E to γ-inert–sterilized direct compression-molded UHMWPE (control). After accelerated aging, the control material showed elevated oxidation, loss of small-punch mechanical properties, and loss of fatigue-crack propagation resistance. In contrast, the vitamin E–stabilized material had minimal changes and exhibited 73% to 86% reduction in wear for both cruciate-retaining and posterior-stabilized total knee arthroplasty designs. Highly cross-linked vitamin E–stabilized UHMWPE performed well in vitro.
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Details
- Title
- Does Vitamin E–Stabilized Ultrahigh-Molecular-Weight Polyethylene Address Concerns of Cross-Linked Polyethylene in Total Knee Arthroplasty?
- Creators
- Hani Haider - University of Nebraska Medical CenterJoel N. Weisenburger - University of Nebraska Medical CenterSteven M. Kurtz - Exponent (United States)Clare M. Rimnac - Case Western Reserve UniversityJordan Freedman - Biomet Inc, Warsaw, IndianaDavid W. Schroeder - Biomet Inc, Warsaw, IndianaKevin L. Garvin - University of Nebraska Medical Center
- Publication Details
- The Journal of arthroplasty, v 27(3), pp 461-469
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000301208500021
- Scopus ID
- 2-s2.0-84857110458
- Other Identifier
- 991019176797504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Orthopedics