Journal article
Does a hypoxic injury from a non-fatal overdose lead to an Alzheimer Disease?
Neurochemistry international, v 143, 104936
01 Feb 2021
PMID: 33309980
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available literature are discussed including neuropathologies associated with opioid and overdose exposures, contributing comorbidities and proteinopathies. Contrasting postmortem data of overdose victims with animal models of opioid neuropathologies and hypoxic injury paints a picture distinct from other proteinopathies as well as effects of moderate opioid exposure. Furthermore the reported biochemical changes and potential targets for therapeutic intervention were mapped pointing to underlying imbalance between tau kinases and phosphatases that is characteristic of Alzheimer Disease.
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Details
- Title
- Does a hypoxic injury from a non-fatal overdose lead to an Alzheimer Disease?
- Creators
- Michael Voronkov - Signum BiosciencesBenjamin Cocchiaro - Community InitiativesJeffry B. Stock - Princeton University
- Publication Details
- Neurochemistry international, v 143, 104936
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Community Health and Prevention
- Web of Science ID
- WOS:000617978800001
- Scopus ID
- 2-s2.0-85097765209
- Other Identifier
- 991022089047104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences