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Journal article
Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women
Menopause (New York, N.Y.), v 21(5), pp 501-508
01 May 2014
PMID: 24149920
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Short-term weight loss is accompanied by bone loss in postmenopausal women. The longer-term impact of weight loss on bone in reduced overweight/obese women compared with women who regained their weight was examined in this study using a case-control design. Methods Postmenopausal women (N = 42; mean [SD] body mass index, 28.3 [2.8] kg/m(2); mean [SD] age, 60.7 [5.5] y) were recruited 2 years after the start of a 6-month weight loss trial; those who maintained their weight (weight loss maintainer [WL-M] group) were matched to a cohort of women who regained their weight (weight loss regainer [WL-R] group). Serum hormones and bone markers were measured in a subset. Bone mineral density (BMD) at the femoral neck, trochanter, spine, radius, and total body, and soft-tissue composition were taken at baseline, 0.5 years, and 2 years. Results During weight loss, both groups lost 9.3% (3.4%) of body weight, with no significant difference between the groups. After weight loss, weight change was -0.1% (2.7%) and 6.0% (3.3%) in the WL-M (n = 22) and WL-R (n = 20) groups, respectively. After 2 years, both groups lost BMD at the femoral neck and trochanter (P <= 0.01), whereas only the WL-M group reduced BMD at the 1/3 radius (P < 0.001). There was greater BMD loss at the trochanter (-6.8% [5.7%]) and 1/3 radius (-4.5% [3.3%]) in the WL-M group compared with the WL-R group after 2 years. Multiple linear regression showed that change in leg fat mass (but not trunk fat) contributed to trochanter BMD loss (P < 0.05). Conclusions After 2 years, there is no BMD recovery of weight reduction-induced bone loss, irrespective of weight regain. These data suggest that the period after weight loss may be an important point in time to prevent bone loss for those who maintain weight and those who regain weight.
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Details
- Title
- Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women
- Creators
- Nancy L. Von Thun - From the 1Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ; and 2Pennington Biomedical Research Center, Baton Rouge, LA.Deeptha Sukumar - Pennington Biomedical Research CenterSteven B. Heymsfield - Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USASue A. Shapses - Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA
- Publication Details
- Menopause (New York, N.Y.), v 21(5), pp 501-508
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- AG12161 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AG012161 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) 0153866 / NJAES
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000335829900012
- Scopus ID
- 2-s2.0-84899918225
- Other Identifier
- 991019231633504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology