Journal article
Donor Hepatic Function: A Factor in Postreperfusion Syndrome
Journal of gastrointestinal surgery, v 6(2), pp 248-254
2002
PMID: 11992811
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Reperfusion of support livers after cold preservation produces hemodynamic instability (i.e., postreperfusion syndrome) in the recipient during both orthotopic liver transplantation and extracorporeal liver perfusion. We evaluated the effect of the normal porcine cold-preserved support liver on healthy recipient hemodynamics and in situ liver function during extracorporeal liver perfusion. Support livers were harvested from Yorkshire pigs and reperfused in an extracorporeal circuit with a healthy, anesthetized recipient pig. Correlation analyses were performed between support liver variables of function (oxygen consumption, bile flow, and biliary phospholipid and cholesterol output) and both recipient hemodynamic stability (heart rate, blood pressure, urine output, and vasopressor use) and hepatic function (bile flow and biliary phospholipid secretion). The data indicate that optimally functioning support livers are associated with improved recipient hemodynamic stability manifested by decreased recipient heart rate and vasopressor use and increased recipient urine output. Support livers exhibiting poor biliary secretory function (i.e., bile flow and phospholipid output) were associated with similarly diminished recipient liver biliary secretory function. These data indicate that the functional condition of the support liver after harvest and cold preservation may influence both recipient hemodynamic parameters and the endogenous function of the recipient liver. (
J Gastrointest Surg 2002;6:248–254.)
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Details
- Title
- Donor Hepatic Function: A Factor in Postreperfusion Syndrome
- Creators
- Rocco Ricciardi - University of Massachusetts Medical SchoolDavid P Foley - University of Massachusetts Medical SchoolSteven H Quarfordt - University of Massachusetts Medical SchoolSusan E Donohue - University of Massachusetts Medical SchoolSuzanne M Wheeler - University of Massachusetts Medical SchoolMark P Callery - Beth Israel Deaconess Medical CenterWilliam C Meyers - Department of Surgery, MCP Hannemann University, Philadelphia, PA USA
- Publication Details
- Journal of gastrointestinal surgery, v 6(2), pp 248-254
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000179920300027
- Scopus ID
- 2-s2.0-0036516669
- Other Identifier
- 991019167436704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology
- Surgery