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Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
Journal article   Open access   Peer reviewed

Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex

Wen-Jun Gao, Yun Wang and Patricia S Goldman-Rakic
The Journal of neuroscience, v 23(5), pp 1622-1630
01 Mar 2003
DOI: https://doi.org/10.1523/JNEUROSCI.23-05-01622.2003
PMID: 12629166
url
https://doi.org/10.1523/JNEUROSCI.23-05-01622.2003View
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Abstract

Interneurons - physiology Synaptic Transmission - physiology Nerve Net - drug effects Nerve Net - physiology Dose-Response Relationship, Drug Neural Inhibition - physiology Prefrontal Cortex - drug effects Dopamine - physiology Dendrites - physiology Pyramidal Cells - physiology Neurons - physiology Synaptic Transmission - drug effects Pyramidal Cells - drug effects Neurons - drug effects Electric Stimulation - methods Action Potentials - drug effects Dopamine Agonists - pharmacology Dopamine - pharmacology Interneurons - drug effects gamma-Aminobutyric Acid - pharmacology Ferrets Prefrontal Cortex - cytology Action Potentials - physiology Patch-Clamp Techniques Animals Dopamine Antagonists - pharmacology In Vitro Techniques Neural Inhibition - drug effects Prefrontal Cortex - physiology
The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D(1) receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.

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