Journal article
Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
The Journal of neuroscience, Vol.23(5), pp.1622-1630
01 Mar 2003
PMCID: PMC6741986
PMID: 12629166
Abstract
The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D(1) receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.
Metrics
6 Record Views
Details
- Title
- Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
- Creators
- Wen-Jun Gao - Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USAYun WangPatricia S Goldman-Rakic
- Publication Details
- The Journal of neuroscience, Vol.23(5), pp.1622-1630
- Publisher
- Society for Neuroscience; United States
- Grant note
- MH44866 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS MH38546 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991014877934704721
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Neurosciences