Journal article
Dopamine, sensory discharge, and stimulus interaction with CO 2 and O 2 in cat carotid body
Journal of applied physiology (1985), v 85(5), pp 1719-1726
01 Nov 1998
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Abstract
It is hypothesized that carotid body chemosensory activity is coupled to neurosecretion. The purpose of this study was to examine whether there was a correspondence between carotid body tissue dopamine (DA) levels and neuronal discharge (ND) measured from the carotid sinus nerve of perfused cat carotid bodies and to characterize interaction between CO
2
and O
2
in these responses. ND and tissue DA were measured after changing from normoxic, normocapnic control bicarbonate buffer ([Formula: see text]>120 Torr, [Formula: see text] 25–30 Torr, pH ∼ 7.4) to normoxic hypercapnia ([Formula: see text] 55–57 Torr, pH 7.1–7.2) or to hypoxic solutions ([Formula: see text] 30–35 Torr) with normocapnia ([Formula: see text] 25–30 Torr, pH ∼ 7.4) or hypocapnia ([Formula: see text]10–15 Torr, pH 7.6–7.8). Similar temporal changes for ND and tissue DA were found for all of the stimuli, although there was a much different proportional relationship for normoxic hypercapnia. Both ND and DA increased above baseline values during flow interruption and normocapnic hypoxia, and both decreased below baseline values during hypoxic hypocapnia. In contrast, normoxic hypercapnia caused an initial increase in ND, from a baseline of 175 ± 12 (SE) to a peak of 593 ± 20 impulses/s within 4.6 ± 0.9 s, followed by adaptation, whereas ND declined to 423 ± 20 impulses/s after 1 min. Tissue DA initially increased from a baseline of 17.9 ± 1.2 μM to a peak of 23.2 ± 1.2 μM within 3.0 ± 0.7 s, then declined to 2.6 ± 1.0 μM. The substantial decrease in tissue DA during normoxic hypercapnia was not consistent with the parallel changes in DA with ND that were observed for hypoxic stimuli.
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Details
- Title
- Dopamine, sensory discharge, and stimulus interaction with CO 2 and O 2 in cat carotid body
- Creators
- D. G. Buerk - University of PennsylvaniaS. Osanai - Departments of Physiology andA. Mokashi - Departments of Physiology andS. Lahiri - Departments of Physiology and
- Publication Details
- Journal of applied physiology (1985), v 85(5), pp 1719-1726
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000076875900018
- Scopus ID
- 2-s2.0-0031739583
- Other Identifier
- 991019231651804721
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- Web of Science research areas
- Physiology
- Sport Sciences