Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults
Brain research, v 1723, pp 146398-146398
15 Nov 2019
PMID: 31442412
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The success of combination antiretroviral therapy (cART) has transformed HIV infection into a chronic condition, resulting in an increase in the number of older, cART-treated adults living with HIV. This has increased the incidence of age-related, non-AIDS comorbidities in this population. One of the most common comorbidities is depression, which is also associated with cognitive impairment and a number of neuropathologies. In older people living with HIV, treating these overlapping disorders is complex, often creating pill burden or adverse drug-drug interactions that can exacerbate these neurologic disorders. Depression, NeuroHIV and many of the neuropsychiatric therapeutics used to treat them impact the dopaminergic system, suggesting that dopaminergic dysfunction may be a common factor in the development of these disorders. Further, changes in dopamine can influence the development of inflammation and the regulation of immune function, which are also implicated in the progression of NeuroHIV and depression. Little is known about the optimal clinical management of drug-drug interactions between cART drugs and antidepressants, particularly in regard to dopamine in older people living with HIV. This review will discuss those interactions, first examining the etiology of NeuroHIV and depression in older adults, then discussing the interrelated effects of dopamine and inflammation on these disorders, and finally reviewing the activity and interactions of CART drugs and antidepressants on each of these factors. Developing better strategies to manage these comorbidities is critical to the health of the aging, HIV-infected population, as the older population may be particularly vulnerable to drug-drug interactions affecting dopamine.
Metrics
Details
- Title
- Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults
- Creators
- Stephanie M. Matt - Drexel UniversityPeter J. Gaskill - Drexel University
- Publication Details
- Brain research, v 1723, pp 146398-146398
- Publisher
- Elsevier
- Number of pages
- 23
- Grant note
- Department of Pharmacology and Physiology at Drexel University College of Medicine R01DA039005 / National Institutes of Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) Brody Family Medical Trust Fund fellowship R01DA039005 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000490627600025
- Scopus ID
- 2-s2.0-85071695674
- Other Identifier
- 991019167930804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences