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Journal article
Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders
Journal of child psychology and psychiatry, v 53(10), pp 1072-1081
01 Oct 2012
PMID: 22827287
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Abstract
Background: Supernumerary sex chromosome aneuploidies (X/Y-aneuploidies), the presence of extra X and/or Y chromosomes, are associated with heightened rates of language impairments and social difficulties. However, no single study has examined different language domains and social functioning in the same sample of children with tri-, tetra-, and pentasomy X/Y-aneuploidy. The current research sought to fill this gap in the literature and to examine dosage effects of X and Y chromosomes on language and social functioning. Methods: Participants included 110 youth with X/Y-aneuploidies (32 female) and 52 with typical development (25 female) matched on age (mean similar to 12 years; range 422) and maternal education. Participants completed the Wechsler intelligence scales, and parents completed the Childrens Communication Checklist-2 and the Social Responsiveness Scale to assess language skills and autistic traits, respectively. Results: Both supernumerary X and Y chromosomes were related to depressed structural and pragmatic language skills and increased autistic traits. The addition of a Y chromosome had a disproportionately greater impact on pragmatic language; the addition of one or more X chromosomes had a disproportionately greater impact on structural language. Conclusions: Given that we link extra X chromosomes with structural language impairments and an extra Y chromosome with pragmatic language impairments, X/Y-aneuploidies may provide clues to genetic mechanisms contributing to idiopathic language impairment and autism spectrum disorders.
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Details
- Title
- Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders
- Creators
- Nancy Raitano Lee - National Institute of Mental HealthGregory L. Wallace - National Institute of Mental HealthElizabeth I. Adeyemi - National Institute of Mental HealthKatherine C. Lopez - National Institute of Mental HealthJonathan D. Blumenthal - National Institute of Mental HealthLiv S. Clasen - National Institute of Mental HealthJay N. Giedd - National Institute of Mental Health
- Publication Details
- Journal of child psychology and psychiatry, v 53(10), pp 1072-1081
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- ZIAMH002794 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) NIH, National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000309238100009
- Scopus ID
- 2-s2.0-84867076609
- Other Identifier
- 991019296577404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Developmental