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Dose-Response Model for Lassa Virus
Journal article   Peer reviewed

Dose-Response Model for Lassa Virus

Sushil B Tamrakar and Charles N Haas
Human and ecological risk assessment, v 14(4), pp 742-752
29 Jul 2008
DOI: https://doi.org/10.1080/10807030802235151
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

dose-response log-probit model beta-Poisson model Lassa fever virus microbial risk assessment exponential model
This article develops dose-response models for Lassa fever virus using data sets found in the open literature. Dose-response data were drawn from two studies in which guinea pigs were given subcutaneous and aerosol exposure to Lassa virus. In one study, six groups of inbred guinea pigs were inoculated subcutaneously with doses of Lassa virus and five groups of out-bred guinea pigs were similarly treated. We found that the out-bred subcutaneously exposed guinea pig did not exhibit a dose-dependent trend in response. The inbred guinea pigs data were best fit by an exponential dose-response model. In a second study, four groups of out-bred guinea pigs were exposed to doses of Lassa virus via the aerosol route. In that study, aerosol diameter was less than 4.5 μ m and both mortality and morbidity were used as endpoints. The log-probit dose-response model provided a somewhat better fit than the Beta-Poisson model for data with mortality as the endpoint, but the Beta-Poisson is considered the best fit model because it can be derived using biological considerations. Morbidity data were best fit with an exponential dose-response model.

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4 citations in Web of Science
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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Biodiversity Conservation
Environmental Sciences
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