Dose-Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers-An in vivo Study

Gagana Karkada; G Arun Maiya; Praveen Arany; Mohandas Rao Kg; Shalini Adiga; Shobha U Kamath

doi:10.1111/php.13754

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Dose-Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers-An in vivo Study

Journal article

Peer reviewed

Dose-Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers-An in vivo Study

Gagana Karkada, G Arun Maiya, Praveen Arany, Mohandas Rao Kg, Shalini Adiga and Shobha U Kamath

Photochemistry and photobiology, Vol.99(4), pp.1172-1180

Jul 2023

DOI: https://doi.org/10.1111/php.13754

PMID: 36477863

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Abstract

Individuals with diabetic foot ulcers have overlapped the inflammatory, proliferative and remodeling phase, making the tissue vulnerable to delayed healing responses. We aimed to establish the dose-response relationship of photobiomodulation therapy of different doses and matrix metalloproteinases in the healing dynamics of diabetic neuropathic ulcers. Diabetes was induced in 126 Albino Wistar rats, and neuropathy was induced to the hind paw by a sciatic nerve injury method. An excisional wound was created on the neuropathy-induced leg. Photobiomodulation therapy of dosages 4, 6, 8, 10, 12 and 15 J cm and wavelength 655 nm and 808 nm was irradiated. Photobiomodulation therapy of dosages 4, 6 and 8 J cm showed better wound healing properties with optimized levels of matrix metalloproteinases-1 and 8. We observed a strong dose response in the experimental group treated with 6 and 8 J cm . The findings from the present study conclude that photobiomodulation therapy of dosages 4, 6 and 8 J cm is suggestive of usefulness in diabetic neuropathic ulcer healing. Markers like matrix metalloproteinases may give a clear direction on response to the therapy. Based on the findings from the present study, we recommend to validate the findings for safety and efficacy in future through human prospective randomized controlled clinical trials.

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Title: Dose-Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers-An in vivo Study
Creators: Gagana Karkada - Manipal Academy of Higher Education
G Arun Maiya - Department of Physiotherapy, Manipal College of Health Professions, Chief-Centre for Diabetic Foot Care and Research, Manipal Academy of Higher Education, Manipal, Karnataka, India
Praveen Arany - University at Buffalo, State University of New York
Mohandas Rao Kg - Department of Anatomy, Melaka Manipal Medical College-Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
Shalini Adiga - Manipal Academy of Higher Education
Shobha U Kamath - Manipal Academy of Higher Education
Publication Details: Photochemistry and photobiology, Vol.99(4), pp.1172-1180
Resource Type: Journal article
Language: English
Academic Unit: Microbiology and Immunology
Web of Science ID: WOS:000917987300001
Scopus ID: 2-s2.0-85146326345
Other Identifier: 991022059934104721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Biochemistry & Molecular Biology; Biophysics