Dose-response model of Coxiella burnetii (Q fever)

Sushil B Tamrakar; Anne Haluska; Charles N Haas; Timothy A Bartrand

doi:10.1111/j.1539-6924.2010.01466.x

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Dose-response model of Coxiella burnetii (Q fever)

Journal article

Open access

Peer reviewed

Dose-response model of Coxiella burnetii (Q fever)

Sushil B Tamrakar, Anne Haluska, Charles N Haas and Timothy A Bartrand

Risk analysis, v 31(1), pp 120-128

Jan 2011

DOI: https://doi.org/10.1111/j.1539-6924.2010.01466.x

PMID: 20723147

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze), Open

Abstract

Guinea Pigs

Humans

Mice, Inbred C57BL

Risk Factors

Virulence

Injections, Intraperitoneal

Bacterial Load

Mice, SCID

Q Fever - microbiology

Likelihood Functions

Animals

Models, Biological

Mice

Q Fever - etiology

Coxiella burnetii - pathogenicity

Disease Models, Animal

Q fever is a zoonotic disease caused by the intracellular gram-negative bacterium Coxiella burnetii (C. burnetii), which only multiplies within the phagolysosomal vacuoles. Q fever may manifest as acute or chronic disease. The acute form is generally not fatal and manifestes as self-controlled febrile illness. Chronic Q fever is usually characterized by endocarditis. Many animal models, including humans, have been studied for Q fever infection through various exposure routes. The studies considered different endpoints including death for animal models and clinical signs for human infection. In this article, animal experimental data available in the open literature were fit to suitable dose-response models using maximum likelihood estimation. Research results for tests of severe combined immunodeficient mice inoculated intraperitoneally (i.p.) with C. burnetii were best estimated with the Beta-Poisson dose-response model. Similar inoculation (i.p.) trial outcomes conducted on C57BL/6J mice were best fit by an exponential model, whereas those tests run on C57BL/10ScN mice were optimally represented by a Beta-Poisson dose-response model.

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Details

Title: Dose-response model of Coxiella burnetii (Q fever)
Creators: Sushil B Tamrakar - Drexel University
Anne Haluska - University of Illinois at Urbana-Champaign
Charles N Haas - Drexel University
Timothy A Bartrand - Drexel University
Publication Details: Risk analysis, v 31(1), pp 120-128
Publisher: Wiley; United States
Number of pages: 9
Resource Type: Journal article
Language: English
Academic Unit: Civil, Architectural, and Environmental Engineering
Web of Science ID: WOS:000285763500012
Scopus ID: 2-s2.0-78650539307
Other Identifier: 991014877660904721

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Collaboration types: Domestic collaboration
Web of Science research areas: Mathematics, Interdisciplinary Applications; Public, Environmental & Occupational Health; Social Sciences, Mathematical Methods