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Journal article
Dosimetric comparison study between intensity modulated radiation therapy and three‐dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer
Journal of applied clinical medical physics, v 11(4), pp 83-92
15 Aug 2010
PMID: 21081882
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective was to compare intensity‐modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in this study. A total of six cervical cancer patients (3 postoperative and 3 intact) were planned and analyzed. All plans had uniform 1.0 cm CTV‐PTV margin and satisfied the 95% PTV with 100% isodose (prescription
dose
=
45
Gy
) coverage. Dose‐volume histograms (DVH) were analyzed for comparison. The overall PTV and PBM volumes were
1035.9
±
192.2
cc and
1151.4
±
198.3
cc, respectively. In terms of PTV dose conformity index (DCI) and dose homogeneity index (DHI), 3DCPT was slightly superior to IMRT with
1.00
±
0.001
,
1.01
±
0.02
, and
1.10
±
0.02
,
1.13
±
0.01
, respectively. In addition, 3DCPT demonstrated superiority in reducing lower doses (i.e., V30 or less) to PBM, small bowel and bladder. Particularly in PBM, average V10 and V20 reductions of 10.8% and
7.4
%
(
p
=
0.001
and 0.04), respectively, were observed. However, in the higher dose range, IMRT provided better sparing
(
>
V
30
)
. For example, in small bowel and PBM, average reductions in V45 of 4.9% and
10.0
%
(
p
=
0.048
and 0.008), respectively, were observed. Due to its physical characteristics such as low entrance dose, spread‐out Bragg peak and finite particle range of protons, 3DCPT illustrated superior target coverage uniformity and sparing of the lower doses in PBM and other organs. Further studies are, however, needed to fully exploit the benefits of protons for general use in cervical cancer.
PACS number: 87.55.D‐, 87.55.dk
Metrics
Details
- Title
- Dosimetric comparison study between intensity modulated radiation therapy and three‐dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer
- Creators
- William Y. Song - University of California San DiegoSoon N. Huh - University of FloridaYun Liang - University of California San DiegoGreg White - University of California San DiegoR. Charles Nichols - University of FloridaW. Tyler Watkins - University of California San DiegoArno J. Mundt - University of California San DiegoLoren K. Mell - University of California San Diego
- Publication Details
- Journal of applied clinical medical physics, v 11(4), pp 83-92
- Publisher
- John Wiley and Sons Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000284215700009
- Scopus ID
- 2-s2.0-78650067776
- Other Identifier
- 991021897493004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging