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Journal article
Double-jeopardy: The joint impact of neighborhood disadvantage and low social cohesion on cumulative risk of disease among African American men and women in the Jackson Heart Study
Social science & medicine (1982), v 153, pp 107-115
01 Mar 2016
PMID: 26894941
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: Few studies have examined the joint impact of neighborhood disadvantage and low social cohesion on health. Moreover, no study has considered the joint impact of these factors on a cumulative disease risk profile among a large sample of African American adults. Using data from the Jackson Heart Study, we examined the extent to which social cohesion modifies the relationship between neighborhood disadvantage and cumulative biological risk (CBR)-a measure of accumulated risk across multiple physiological systems.
Methods: Our analysis included 4408 African American women and men ages 21-85 residing in the Jackson, MS Metropolitan Area. We measured neighborhood disadvantage using a composite score of socioeconomic indicators from the 2000 US Census and social cohesion was assessed using a 5-item validated scale. Standardized z-scores of biomarkers representing cardiovascular, metabolic, inflammatory, and neuroendocrine systems were combined to create a CBR score. We used two-level linear regression models with random intercepts adjusting for socio-demographic and behavioral covariates in the analysis. A three-way interaction term was included to examine whether the relationship between neighborhood disadvantage and CBR differed by levels of social cohesion and gender.
Results: The interaction between neighborhood disadvantage, social cohesion and gender was statistically significant (p = 0.05) such that the association between living in a disadvantaged neighborhood and CBR was strongest for men living in neighborhoods with low levels of social cohesion (B = 0.63, SE: 032). In gender-specific models, we found a statistically significant interaction between neighborhood disadvantage and social cohesion for men (p = 0.05) but not for women (p = 0.50).
Conclusion: Neighborhoods characterized by high levels of economic disadvantage and low levels of social cohesion contribute to higher cumulative risk of disease among African American men. This suggests that they may face a unique set of challenges that put them at greater risk in these settings. (C) 2016 Elsevier Ltd. All rights reserved.
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Details
- Title
- Double-jeopardy: The joint impact of neighborhood disadvantage and low social cohesion on cumulative risk of disease among African American men and women in the Jackson Heart Study
- Creators
- Sharrelle Barber - Harvard UniversityDeMarc A. Hickson - My Brother's KeeperIchiro Kawachi - Harvard UniversityS. V. Subramanian - Harvard UniversityFelton Earls - Harvard University
- Publication Details
- Social science & medicine (1982), v 153, pp 107-115
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- U01PS003315 / National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP); United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA National Institutes of Health National Research Service; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CVD Epidemiology Training Program in Behavior CIAHD: Michigan Center for Integrative Approaches to Health Disparities - National Institute on Minority Health and Health Disparities R25GM055353 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P60MD002249 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) T32 HL 098048-02 / Environment and Global Health R01 HL071759 / MESA Neighborhood Study - National Institutes of Health, National Heart, Lung, and Blood Institute T32HL098048 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 5 R25 GM 055353 / NIH Initiative to Maximize Student Diversity; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) P60 MD002249 05S1 / EPA and NIMHD: Environment HHSN268201300046C; HHSN268201300047C; HHSN268201300048C; HHSN268201300049C; HHSN268201300050C / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R25MH083620 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000372937500013
- Scopus ID
- 2-s2.0-84958190909
- Other Identifier
- 991019167624404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Social Sciences, Biomedical