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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Double life: How GRK2 and β-arrestin signaling participate in diseases
Cellular signalling, v 94, pp 110333-110333
Jun 2022
PMID: 35430346
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
G-protein coupled receptor (GPCR) kinases (GRKs) and β-arrestins play key roles in GPCR and non-GPCR cellular responses. In fact, GRKs and arrestins are involved in a plethora of pathways vital for physiological maintenance of inter- and intracellular communication. Here we review decades of research literature spanning from the discovery, identification of key structural elements, and findings supporting the diverse roles of these proteins in GPCR-mediated pathways. We then describe how GRK2 and β-arrestins partake in non-GPCR signaling and briefly summarize their involvement in various pathologies. We conclude by presenting gaps in knowledge and our prospective on the promising pharmacological potential in targeting these proteins and/or downstream signaling. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and arrestins in metabolism and disease progression.
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Details
- Title
- Double life: How GRK2 and β-arrestin signaling participate in diseases
- Creators
- Ruxu Zhai - Drexel UniversityJonathan Snyder - Drexel UniversitySarah Montgomery - Drexel UniversityPriscila Y Sato - Drexel University
- Publication Details
- Cellular signalling, v 94, pp 110333-110333
- Publisher
- Elsevier
- Grant note
- R56 HL149887 / NHLBI NIH HHS R01 HL163666 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000799587100001
- Scopus ID
- 2-s2.0-85128459346
- Other Identifier
- 991019167781104721
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- Web of Science research areas
- Cell Biology