Double life: How GRK2 and β-arrestin signaling participate in diseases

Ruxu Zhai; Jonathan Snyder; Sarah Montgomery; Priscila Y Sato

doi:10.1016/j.cellsig.2022.110333

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Double life: How GRK2 and β-arrestin signaling participate in diseases

Journal article

Open access

Peer reviewed

Double life: How GRK2 and β-arrestin signaling participate in diseases

Ruxu Zhai, Jonathan Snyder, Sarah Montgomery and Priscila Y Sato

Cellular signalling, Vol.94, pp.110333-110333

Jun 2022

DOI: https://doi.org/10.1016/j.cellsig.2022.110333

PMID: 35430346

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Abstract

Arrestins - metabolism

beta-Arrestin 1 - metabolism

beta-Arrestin 2 - metabolism

beta-Arrestins - metabolism

G-Protein-Coupled Receptor Kinases - metabolism

Phosphorylation

Receptors, G-Protein-Coupled - metabolism

Signal Transduction - physiology

G-protein coupled receptor (GPCR) kinases (GRKs) and β-arrestins play key roles in GPCR and non-GPCR cellular responses. In fact, GRKs and arrestins are involved in a plethora of pathways vital for physiological maintenance of inter- and intracellular communication. Here we review decades of research literature spanning from the discovery, identification of key structural elements, and findings supporting the diverse roles of these proteins in GPCR-mediated pathways. We then describe how GRK2 and β-arrestins partake in non-GPCR signaling and briefly summarize their involvement in various pathologies. We conclude by presenting gaps in knowledge and our prospective on the promising pharmacological potential in targeting these proteins and/or downstream signaling. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and arrestins in metabolism and disease progression.

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Details

Title: Double life: How GRK2 and β-arrestin signaling participate in diseases
Creators: Ruxu Zhai - Drexel University
Jonathan Snyder - Drexel University
Sarah Montgomery - Drexel University
Priscila Y Sato - Drexel University
Publication Details: Cellular signalling, Vol.94, pp.110333-110333
Publisher: Elsevier
Grant note: R56 HL149887 / NHLBI NIH HHS R01 HL163666 / NHLBI NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Pharmacology and Physiology
Identifiers: 991019167781104721

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Web of Science research areas: Cell Biology

Double life: How GRK2 and β-arrestin signaling participate in diseases

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