Journal article
Down syndrome with low hypodiploidy in precursor B-cell acute lymphoblastic leukemia
Cancer genetics and cytogenetics, v 169(1)
2006
PMID: 16875938
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We describe the rare finding of a 33-month-old child neonatally diagnosed with Down syndrome, who presented with pre-B acute lymphoblastic leukemia (ALL) with a pretreatment bone marrow karyotype in which a low hypodiploid cell line (38 chromosomes) was identified in 17/19 cells studied. The abnormal cell line retained the extra constitutional chromosome 21. Hypodiploidy (loss of one or more chromosomes) is seen in approximately 5% of all childhood pre-B ALL cases and in approximately 2.2% cases of individuals with a constitutional trisomy 21. Low hypodiploidy, associated with a high risk of relapse, is rare in pediatric ALL cases in the general population, and, to our knowledge, is previously unreported in patients with trisomy 21.
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Details
- Title
- Down syndrome with low hypodiploidy in precursor B-cell acute lymphoblastic leukemia
- Creators
- Jennifer J.D. Morrissette - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical PathologyGregory E. Halligan - St. Christopher's Hospital for ChildrenHope H. Punnett - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical PathologyAnn Shoemaker McKenzie - St. Christopher's Hospital for ChildrenFelicula Guerrero - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical PathologyJ.P. de Chadarévian - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical Pathology
- Publication Details
- Cancer genetics and cytogenetics, v 169(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000239678100009
- Scopus ID
- 2-s2.0-33746237637
- Other Identifier
- 991019169601404721
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- Web of Science research areas
- Genetics & Heredity
- Oncology