Journal article
Doxorubicin and 5-fluorouracil plasma concentrations and detectability in parotid saliva
European journal of clinical pharmacology, v 24(2), pp 261-266
1983
PMID: 6840177
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Doxorubicin and 5-fluorouracil pharmacokinetics were studied in 19 volunteers with various advanced neoplastic diseases who received 50-90 mg doxorubicin or 600-1000 mg 5-fluorouracil intravenously, followed by plasma and parotid saliva collection over a 75 min period. The extent to which these chemotherapeutic agents are bound to plasma proteins, at concentrations chosen to approximate plasma concentrations, was measured by equilibrium dialysis. Both agents were quantitated by high-performance liquid chromatography. As reported previously, a wide range of plasma levels were found among patients receiving similar doses of either doxorubicin or 5-fluorouracil. It appears that in addition to being quickly cleared from the plasma both chemotherapeutic agents are excreted in detectable amounts in parotid saliva, a route of elimination heretofore given little or no attention. Excretion in the saliva exposes the mucosa of the upper gastrointestinal tract to 5-fluorouracil after intravenous administration and may play a part in causing stomatitis in patients receiving it by this route. Since there are huge interindividual and pronounced intraindividual differences in S/P ratios mostly not systematically related to the drugs' concentration in plasma, the concentration in parotid saliva was not useful in predicting the level of free doxorubicin or 5-fluorouracil in plasma.
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Details
- Title
- Doxorubicin and 5-fluorouracil plasma concentrations and detectability in parotid saliva
- Creators
- L A Celio - Drexel UniversityG J DiGregorio - Drexel UniversityE Ruch - Drexel UniversityJ PaceA J Piraino - Drexel University
- Publication Details
- European journal of clinical pharmacology, v 24(2), pp 261-266
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:A1983QG42100022
- Scopus ID
- 2-s2.0-0020677554
- Other Identifier
- 991019184042004721
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- Web of Science research areas
- Pharmacology & Pharmacy