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Doxylamine Overdose as a Potential Cause of Rhabdomyolysis
Journal article   Peer reviewed

Doxylamine Overdose as a Potential Cause of Rhabdomyolysis

Biana Leybishkis, Panayotis Fasseas and Kathleen Ryan
The American journal of the medical sciences, v 322(1), pp 44-47
Jul 2001
DOI: https://doi.org/10.1097/00000441-200107000-00009
PMID: 11465247
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Doxylamine succinate, an over-the-counter antihistamine, is commonly used as a nighttime sleep aid in the short-term management of insomnia. It is also used in combination with antitussive and decongestant agents for the temporary relief of common cold symptoms. Doxylamine is frequently involved in accidental and intentional overdoses. Rhabdomyolysis and secondary acute renal failure are rare but potentially serious complications, making early recognition and treatment essential. With the large number of nonprescription antihistamines and sleep aids available to the general public, it is important to keep in mind that overdose is a potential problem. The complications associated with overdose of these medications are just as life threatening as those associated with prescription drugs. A high index of suspicion and evaluation of rhabdomyolysis is warranted in antihistamine toxicity. We report an observation of severe rhabdomyolysis associated with doxylamine overdose.

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18 citations in Web of Science
21 citations in Scopus

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Web of Science research areas
Toxicology
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