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Journal article
Drinking Water Contamination and the Incidence of Leukemia and Non-Hodgkin's Lymphoma
Environmental health perspectives, v 102(6/7), pp 556-561
01 Jun 1994
PMID: 9679115
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A study of drinking water contamination and leukemia and non-Hodgkin's lymphoma (NHL) incidence (1979-1987) was conducted in a 75-town study area. Comparing incidence in towns in the highest trichloroethylene (TCE) stratum (>5 µg/1) to towns without detectable TCE yielded an age-adjusted rate ratio (RR) for total leukemia among females of 1.43 (95% CI 1.07-1.90). For females under 20 years old, the RR for acute lymphocytic leukemia was 3.26 (95% CI 1.27-8.15). Elevated RRs were observed for chronic myelogenous leukemia among females and for chronic lymphocytic leukemia among males and females. NHL incidence among women was also associated with the highest TCE stratum (RR = 1.36; 95% CI 1.08-1.70). For diffuse large cell NHL and non-Burkitt's high-grade NHL among females, the RRs were 1.66 (95% CI 1.07-2.59) and 3.17 (95% CI 1.23-8.18), respectively, and 1.59 (95% CI 1.04-2.43) and 1.92 (95% CI 0.54-6.81), respectively, among males. Perchloroethylene (PCE) was associated with incidence of non-Burkitt's high-grade NHL among females, but collinearity with TCE made it difficult to assess relative influences. The results suggest a link between TCE/PCE and leukemia/ NHL incidence. However, the conclusions are limited by potential misclassification of exposure due to lack of individual information on longterm residence, water consumption, and inhalation of volatilized compounds.
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Details
- Title
- Drinking Water Contamination and the Incidence of Leukemia and Non-Hodgkin's Lymphoma
- Creators
- Perry CohnJudith Klotz - New Jersey Department of HealthFrank Bove - New Jersey Department of HealthMarian Berkowitz - New Jersey Department of HealthJerald Fagliano - New Jersey Department of Health
- Publication Details
- Environmental health perspectives, v 102(6/7), pp 556-561
- Publisher
- National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:A1994PA77300011
- Scopus ID
- 2-s2.0-0028092825
- Other Identifier
- 991021871326804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology