Journal article
Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)
Advanced materials (Weinheim), v 31(17), 1970120
25 Apr 2019
Abstract
In article number 1806957, Weiyue Lu, Zhen Gu, and co‐workers engineer a dual bioresponsive drug‐delivery depot that can respond to the acidic pH and reactive oxygen species within the tumor microenvironment for co‐delivery of anti‐PD1 antibody and an epigenetic modulator. This combination therapy increases the immunogenicity of cancer cells and enhances the antitumor immune response. The pond represents the drug‐delivery depot, the duckweeds represent the tumor cells; the red fish (epigenetic agent) and the black fish (aPD1 antibody) work together to eat the duckweeds, representing the tumor cells being eliminated.
Metrics
4 Record Views
Details
- Title
- Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)
- Creators
- Huitong Ruan - University of California, Los AngelesQuanyin Hu - University of California, Los AngelesDi Wen - University of California, Los AngelesQian Chen - University of California, Los AngelesGuojun Chen - University of California, Los AngelesYifei Lu - University of California, Los AngelesJinqiang Wang - University of California, Los AngelesHao Cheng - Drexel UniversityWeiyue Lu - Fudan UniversityZhen Gu - University of California, Los Angeles
- Publication Details
- Advanced materials (Weinheim), v 31(17), 1970120
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Other Identifier
- 991021886802004721