Journal article
Drug History Modifies the Behavioral Effects of Pentobarbital
Science (American Association for the Advancement of Science), v 220(4594), pp 333-335
15 Apr 1983
PMID: 6682244
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Abstract
Behavior of squirrel monkeys, maintained by the termination of stimuli associated with electric shock, was suppressed by response-dependent shock delivery. The effects of pentobarbital on this behavior depended on whether monkeys had previously received morphine. In monkeys without experience with drugs, pentobarbital increased responding. In monkeys with recent experience with morphine, however, pentobarbital resulted in a smaller increase or decrease in responding. The rate-decreasing effects of pentobarbital after a history of morphine administration could be reversed by the administration of d-amphetamine. These findings suggest that the behavioral effects of abused drugs may depend on previous experience with other drugs, even when those drugs are from a different pharmacological class.
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Details
- Title
- Drug History Modifies the Behavioral Effects of Pentobarbital
- Creators
- John R. GlowaJames E. Barrett
- Publication Details
- Science (American Association for the Advancement of Science), v 220(4594), pp 333-335
- Publisher
- The American Association for the Advancement of Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:A1983QJ80900042
- Scopus ID
- 2-s2.0-0020622031
- Other Identifier
- 991020836357804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy