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Drug adherence in Parkinson's disease
Journal article   Open access   Peer reviewed

Drug adherence in Parkinson's disease

Norman A Leopold, Marcia Polansky and Marcia R Hurka
Movement disorders, v 19(5), pp 513-517
May 2004
DOI: https://doi.org/10.1002/mds.20041
PMID: 15133814
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1002/mds.20041View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Aged Antiparkinson Agents - administration & dosage Antiparkinson Agents - therapeutic use Carbidopa - administration & dosage Carbidopa - therapeutic use Chronic Disease Drug Administration Schedule Drug Combinations Drug Monitoring - methods Female Humans Levodopa - administration & dosage Levodopa - therapeutic use Male Medication Systems Parkinson Disease - drug therapy Patient Compliance - statistics & numerical data Surveys and Questionnaires
Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor medication use, nonadherence of drug use was examined in subjects with Parkinson's disease (PD). We report that prescription nonadherence in PD subjects was common and approximated that reported in other chronic diseases. During a 28-day observation period, only 4 of 39 subjects had complete schedule adherence, i.e., no missed, extra, or mistimed doses. Using a questionnaire, 24.3% of subjects acknowledged missing any doses but the computerized MEMS recorded that 51.3% of subjects missed at least one dose per week and 20.5% of subjects missed three or more doses per week. Mistiming of doses was admitted by 73% of subjects but 82.1% had recorded mistimed doses. Of multiple sociodemographic and disease-related items examined, only gender and level of education were statistically related to nonadherence.

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116 citations in Web of Science
123 citations in Scopus

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Web of Science research areas
Clinical Neurology
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