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Journal article
Drug delivery strategies to control macrophages for tissue repair and regeneration
Experimental biology and medicine (Maywood, N.J.), v 241(10), pp 1054-1063
01 May 2016
PMID: 27190256
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity to regenerate damaged tissues in many situations. However, tissue healing is impaired in injuries that exceed a critical size or are exacerbated by chronic inflammatory diseases like diabetes. In these instances, biomaterials and drug delivery strategies are often required to facilitate tissue regeneration by providing physical and biochemical cues. Inflammation is the body's response to injury. It is critical for wound healing and biomaterial integration and vascularization, as long as the timing is well controlled. For example, chronic inflammation is well known to impair healing in chronic wounds. In this review, we highlight the importance of a well-controlled inflammatory response, primarily mediated by macrophages in tissue repair and regeneration and discuss various strategies designed to promote regeneration by controlling macrophage behavior. These strategies include temporally controlled delivery of anti-inflammatory drugs, delivery of macrophages as cellular therapy, controlled release of cytokines that modulate macrophage phenotype, and the design of nanoparticles that exploit the inherent phagocytic behavior of macrophages. A clear outcome of this review is that a deeper understanding of the role and timing of complex macrophage phenotypes or activation states is required to fully harness their abilities with drug delivery strategies.
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Details
- Title
- Drug delivery strategies to control macrophages for tissue repair and regeneration
- Creators
- Reham Garash - Drexel UniversityAnamika Bajpai - Drexel UniversityBrandon M. Marcinkiewicz - Drexel UniversityKara L. Spiller - Drexel University
- Publication Details
- Experimental biology and medicine (Maywood, N.J.), v 241(10), pp 1054-1063
- Publisher
- Sage
- Number of pages
- 10
- Grant note
- R01HL130037 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 1R01 HL130037-01 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Drexel-Coulter Translational Research Partnership
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000377197400005
- Scopus ID
- 2-s2.0-84971493191
- Other Identifier
- 991019168806804721
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- Web of Science research areas
- Medicine, Research & Experimental