Journal article
Drug release through liposome pores
Colloids and surfaces, B, Biointerfaces, v 126
01 Feb 2015
PMID: 25546834
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Release through liposomal surface pores depends on the pore surface area, pore size and distribution.•Release through pores that cover only a fraction of the surface area can approach the rate of fully ruptured systems.•At fixed pore surface coverage, the release rate decreases with increasing pore size in the limit of low coverage, but not at relatively high pore surface area.•At fixed pore surface coverage and pore size, the distribution of pores affects the release in the limit of high surface coverage, but not at low pore densities.
Electrical, ultrasound and other types of external fields are known to induce the formation of pores in cellular and model membranes. This paper examines drug release through field induced liposome pores using Monte Carlo simulations. We find that drug release rates vary as a function of pore size and spacing, as well as the overall fraction of surface area covered by pores: The rate of release from liposomes is found to increase rapidly with pore surface coverage, approaching that of the fully ruptured liposome at fractional pore areas. For a given pore surface coverage, the pore size affects the release rate in the limit of low coverage, but not when the pores cover a relatively high fraction of the liposome surface area. On the other hand, for a given pore size and surface coverage, the distribution of pores significantly affects the release in the limit of high surface coverage: The rate of release from a liposome covered with a regularly spaced array of pores is, in this limit, higher than the release rate from (most) systems where the pores are distributed randomly on the liposome surface. In contrast, there is little effect of the pore distribution on release when the pore surface coverage is low. The simulation results are in good agreement with the predictions of detailed diffusion models.
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Details
- Title
- Drug release through liposome pores
- Creators
- Nily Dan - Drexel University
- Publication Details
- Colloids and surfaces, B, Biointerfaces, v 126
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000350918900011
- Scopus ID
- 2-s2.0-84919935287
- Other Identifier
- 991019312450904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biophysics
- Chemistry, Physical
- Materials Science, Biomaterials