Journal article
Drug treatments for polycystic ovary syndrome
American family physician, v 79(8), pp 671-676
15 Apr 2009
PMID: 19405411
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. Diagnosis can be difficult because the signs and symptoms can be subtle and varied. These may include hirsutism, infertility, menstrual irregularities, and biochemical abnormalities, most notably insulin resistance. Treatment should target specific manifestations and individualized patient goals. When choosing a treatment regimen, physicians must take into account comorbidities and the patient's desire for pregnancy. Lifestyle modifications should be used in addition to medical treatments for optimal results. Few agents have been approved by the U.S. Food and Drug Administration specifically for use in polycystic ovary syndrome, and several agents are contraindicated in pregnancy. Insulin-sensitizing agents are indicated for most women with polycystic ovary syndrome because they have positive effects on insulin resistance, menstrual irregularities, anovulation, hirsutism, and obesity. Metformin has the most data supporting its effectiveness. Rosiglitazone and pioglitazone are also effective for ameliorating hirsutism and insulin resistance. Metformin and clomiphene, alone or in combination, are first-line agents for ovulation induction. Insulin-sensitizing agents, oral contraceptives, spironolactone, and topical eflornithine can be used in patients with hirsutism.
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Details
- Title
- Drug treatments for polycystic ovary syndrome
- Creators
- Lee Radosh - Reading Hospital
- Publication Details
- American family physician, v 79(8), pp 671-676
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Family (Community and Preventive) Medicine
- Web of Science ID
- WOS:000265251200005
- Scopus ID
- 2-s2.0-66149134463
- Other Identifier
- 991019168320004721
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- Web of Science research areas
- Primary Health Care