Journal article
Dual-opposite-injection CZE: theoretical aspects and application to organic and pharmaceutical compounds
Electrophoresis, v 28(4), pp 697-711
Feb 2007
PMID: 17253631
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Abstract
Several important figures of merit (migration time, efficiency, resolution, resolution per unit time, and electrophoretic selectivity) are quantitatively compared for the first time for conventional CZE and dual-opposite-injection CZE (DOI-CZE). Aspects of DOI-CZE relevant to the separation of organic and pharmaceutical ions (MW>120 Da) are also discussed. Two new approaches to resolve the codetection of anions and cations, hydrodynamic flow-modified DOI-CZE and polarity reversal in combination with asymmetric detector window positioning, are compared with the method of preliminary transport, a variable procedure within sequential sample introduction, using a six-component sample of organic and pharmaceutical compounds. The advantages of DOI-CZE for the simultaneous analysis of organic/pharmaceutical anions and cations are illustrated in a direct comparison of conventional CZE and DOI-CZE for the separation of a ten-component mixture of pharmaceutical ions (five ionized acids and five ionized bases).
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Details
- Title
- Dual-opposite-injection CZE: theoretical aspects and application to organic and pharmaceutical compounds
- Creators
- Brian S Weekley - Analytical R&D, Pfizer Global Research and Development, Ann Arbor, MI, USAJoe P Foley
- Publication Details
- Electrophoresis, v 28(4), pp 697-711
- Publisher
- Wiley; Germany
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000245062300024
- Scopus ID
- 2-s2.0-33947140473
- Other Identifier
- 991014878530804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical