Journal article
Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications
The Journal of biological chemistry, v 290(48), pp 28596-28603
27 Nov 2015
PMID: 26453298
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory. During the last decade, posttranslational modifications have emerged as critical regulators of synaptic transmission and plasticity. Notably, phosphorylation, ubiquitination, and palmitoylation control the stability, trafficking, and synaptic expression of glutamate receptors in the central nervous system. In the current review, we will summarize some of the progress made by the neuroscience community regarding our understanding of phosphorylation, ubiquitination, and palmitoylation of the NMDA and AMPA subtypes of glutamate receptors.
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Details
- Title
- Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications
- Creators
- Marc P. Lussier - Université du Québec à MontréalAntonio Sanz-Clemente - Northwestern UniversityKatherine W. Roche - National Institutes of Health
- Publication Details
- The Journal of biological chemistry, v 290(48), pp 28596-28603
- Publisher
- Amer Soc Biochemistry Molecular Biology Inc
- Number of pages
- 8
- Grant note
- 1K99AG041225 / National Institutes of Health NIA Grant NINDS Intramural Program Universite du Quebec a Montreal Start-up Funds R00AG041225 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) ZIANS002994 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000365762300002
- Scopus ID
- 2-s2.0-84948459315
- Other Identifier
- 991020099169904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology