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Journal article
Dynamic changes in arterial pressure following high cervical transection in the decerebrate rat
The journal of spinal cord medicine, v 44(3), pp 399-410
04 May 2021
PMID: 31525149
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Spinal transection has variable effects on arterial pressure, with some investigators demonstrating a precipitous decline and others reporting only a minimal decrease below normal. Recovery of arterial pressure following spinalization occurs with varying time courses - in some cases over days and in others over weeks to months. Given these findings, we sought to systematically test the hypothesis that in the unanesthetized decerebrate rat, arterial pressure would recover to pre-transection values over an acute time course. Design: Experiments were performed on a total of six Sprague-Dawley unanesthetized decerebrate adult male rats. In four rats, we determined dynamic changes in arterial pressure and heart rate in response to C-1 transection. Results: Immediately following spinal cord injury, there were significant decreases in systolic blood (SBP) and mean arterial pressure (MAP), but not diastolic blood pressure (DBP). SBP, DBP, and MAP were significantly greater 170 min post-transection compared to immediate and 5 min-post transection values and were not statistically significantly different from pre-transection control. Heart rate decreased significantly following transection, but not immediately following the spinal cord injury. Lung inflation elicited depressor responses in all animals tested (n = 4 animals) and in three animals resulted in bradycardia. Hypercapnia tests effected a decrease in arterial pressure and heart rate (n = 3 animals). Conclusions: We demonstrate that in the unanesthetized decerebrate spinalized animal, arterial pressure is reduced by spinal transection and recovers over an acute time course to pre-transection values.
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Details
- Title
- Dynamic changes in arterial pressure following high cervical transection in the decerebrate rat
- Creators
- Michael George Zaki Ghali - Drexel University
- Publication Details
- The journal of spinal cord medicine, v 44(3), pp 399-410
- Publisher
- Taylor & Francis
- Number of pages
- 12
- Grant note
- 224089 / Craig H. Neilsen Foundation
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000486887500001
- Scopus ID
- 2-s2.0-85073815312
- Other Identifier
- 991019312476204721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology