Journal article
Dynamic coupling of blood flow to function and metabolism in the optic nerve head
Neuro-ophthalmology (Amsterdam : Aeolus Press. 1980), v 20(2), pp 45-54
1998
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Abstract
Increased neuronal activity induced by diffuse flickering illumination of the ocular fundus generates increases in blood flow and decreases in tissue pO 2 in the optic nerve head (ONH). This suggests that in the ONH, as in the brain, a coupling exists between function, perfusion, and metabolism, in accordance with the hypothesis of Roy and Sherrington. Following a review of the characteristics of the activity-induced blood flow response in the cat ONH, the relationship between blood flow and metabolism is discussed. We then examine possible mediators of the neurovascular coupling, some of the factors which may interfere with it, and point out various problems which remain to be addressed in order to better understand this coupling.
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Details
- Title
- Dynamic coupling of blood flow to function and metabolism in the optic nerve head
- Creators
- Charles E. Riva - University of LausanneDonald G. Buerk - University of Pennsylvania
- Publication Details
- Neuro-ophthalmology (Amsterdam : Aeolus Press. 1980), v 20(2), pp 45-54
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000075888700002
- Scopus ID
- 2-s2.0-0031712165
- Other Identifier
- 991019231658004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Ophthalmology