Journal article
Dynamics of plaque formation in Alzheimer's disease
Biophysical journal, Vol.76(3), pp.1330-1334
Mar 1999
PMCID: PMC1300112
PMID: 10049316
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Abstract
Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-beta peptide. We analyze the time evolution of amyloid-beta deposition in immunostained brain slices from transgenic mice. We find that amyloid-beta deposits appear in clusters whose characteristic size increases from 14 microm in 8-month-old mice to 22 microm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-beta by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.
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Details
- Title
- Dynamics of plaque formation in Alzheimer's disease
- Creators
- B Urbanc - Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 USAL CruzS V BuldyrevS HavlinM C IrizarryH E StanleyB T Hyman
- Publication Details
- Biophysical journal, Vol.76(3), pp.1330-1334
- Publisher
- Elsevier; United States
- Grant note
- AG08487 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Identifiers
- 991014878290004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics