Dynamics of plaque formation in Alzheimer's disease

B Urbanc; L Cruz; S V Buldyrev; S Havlin; M C Irizarry; H E Stanley; B T Hyman

doi:10.1016/S0006-3495(99)77295-4

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Dynamics of plaque formation in Alzheimer's disease

Journal article

Open access

Peer reviewed

Dynamics of plaque formation in Alzheimer's disease

B Urbanc, L Cruz, S V Buldyrev, S Havlin, M C Irizarry, H E Stanley and B T Hyman

Biophysical journal, Vol.76(3), pp.1330-1334

Mar 1999

DOI: https://doi.org/10.1016/S0006-3495(99)77295-4

PMCID: PMC1300112

PMID: 10049316

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Abstract

Alzheimer Disease - etiology

Immunohistochemistry

Biophysical Phenomena

Plaque, Amyloid - pathology

Humans

Plaque, Amyloid - chemistry

Mice, Transgenic

Biophysics

Alzheimer Disease - pathology

Macromolecular Substances

Particle Size

Animals

Time Factors

Amyloid beta-Peptides - genetics

Alzheimer Disease - metabolism

Amyloid beta-Peptides - metabolism

Plaque, Amyloid - metabolism

Mice

Amyloid beta-Peptides - chemistry

Kinetics

Disease Models, Animal

Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-beta peptide. We analyze the time evolution of amyloid-beta deposition in immunostained brain slices from transgenic mice. We find that amyloid-beta deposits appear in clusters whose characteristic size increases from 14 microm in 8-month-old mice to 22 microm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-beta by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.

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Title: Dynamics of plaque formation in Alzheimer's disease
Creators: B Urbanc - Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 USA
L Cruz
S V Buldyrev
S Havlin
M C Irizarry
H E Stanley
B T Hyman
Publication Details: Biophysical journal, Vol.76(3), pp.1330-1334
Publisher: Elsevier; United States
Grant note: AG08487 / NIA NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Physics
Identifiers: 991014878290004721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Biophysics

Dynamics of plaque formation in Alzheimer's disease

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Abstract

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UN Sustainable Development Goals (SDGs)

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