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Journal article
Dysexecutive Functioning in Mild Cognitive Impairment: Derailment in Temporal Gradients
Journal of the International Neuropsychological Society, v 18(1)
01 Jan 2012
PMID: 22014116
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Libon et al. (2010) provided evidence for three statistically determined clusters of patients with mild cognitive impairment (MCI): amnesic (aMCI), dysexecutive (dMCI), and mixed (mxMCI). The current study further examined dysexecutive impairment in MCI using the framework of Fuster's (1997) derailed temporal gradients, that is, declining performance on executive tests over time or test epoch. Temporal gradients were operationally defined by calculating the slope of aggregate letter fluency output across 15-s epochs and accuracy indices for initial, middle, and latter triads from the Wechsler Memory Scale-Mental Control subtest (Boston Revision). For letter fluency, slope was steeper for dMCI compared to aMCI and NC groups. Between-group Mental Control analyses for triad 1 revealed worse dMCI performance than NC participants. On triad 2, dMCI scored lower than aMCI and NCs; on triad 3, mxMCI performed worse versus NCs. Within-group Mental Control analyses yielded equal performance across all triads for aMCI and NC participants. mxMCI scored lower on triad 1 compared to triads 2 and 3. dMCI participants also performed worse on triad 1 compared to triads 2 and 3, but scored higher on triad 3 versus triad 2. These data suggest impaired temporal gradients may provide a useful heuristic for understanding dysexecutive impairment in MCI. (JINS, 2012, 18, 20-28)
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Details
- Title
- Dysexecutive Functioning in Mild Cognitive Impairment: Derailment in Temporal Gradients
- Creators
- Joel Eppig - Drexel UniversityDenene Wambach - Drexel UniversityChristine Nieves - Drexel UniversityCatherine C. Price - University of Florida HealthMelissa Lamar - University of Illinois at ChicagoLisa Delano-Wood - University of California, San DiegoTania Giovannetti - Temple UniversityBrianne M. Bettcher - Lahey Hospital and Medical CenterDana L. Penney - Lahey Hospital and Medical CenterRod Swenson - North Dakota State UniversityCarol Lippa - Drexel UniversityAnahid Kabasakalian - Drexel UniversityMark W. Bondi - University of California, San DiegoDavid J. Libon - Drexel University
- Publication Details
- Journal of the International Neuropsychological Society, v 18(1)
- Publisher
- Cambridge Univ Press
- Number of pages
- 9
- Grant note
- UL1TR000064 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) K24 AG026431; R01 AG012674 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) UL1 TR000064 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) K23NS060660 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) K23 NS060660; K23 NS060660-05 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) K24AG026431 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000298958800002
- Scopus ID
- 2-s2.0-84855167032
- Other Identifier
- 991019312448204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology