Journal article
EFFECTS OF THE RIBAVIRIN-INTERFERON α COMBINATION ON CULTURED PERIPHERAL BLOOD MONONUCLEAR CELLS FROM CHRONIC HEPATITIS C PATIENTS
Cytokine (Philadelphia, Pa.), v 10(8), pp 635-644
01 Aug 1998
PMID: 9722937
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of ribavirin and interferon (IFN) α have been investigated on cultured peripheral blood mononuclear cells, obtained from 15 patients with chronic hepatitis C virus (HCV) infection. At clinically relevant serum concentrations achieved during therapeutic administration, ribavirin did inhibit moderately the mitogen-stimulated mononuclear cell proliferation and growth of the CD4+and CD8+T cell subsets without apparent cytolysis. The ribavirin-IFN-α combination showed activity against HCV with disappearance of HCV RNA in 27% of cases, and a synergy in the inducibility of the intracellular enzyme 2′,5′ -oligoadenylate synthetase. Such ribavirin concentrations induced modest increases in the T helper 1-like cytokine production by mononuclear cells. Higher ribavirin concentrations markedly inhibited IFN-γ production, but augmented interleukins 2, 4, and 12 secretion. Conversely, IFN-α tended to suppress interleukins 2, 4 and 12, but enhanced IFN-γ and interleukin 10 secretion. Thus, ribavirin and IFN-α appear to cause diverse effects on immunoregulatory cytokine secretion, and when combined, counteracted for production of IL-2 and IL-12, while upregulated mononuclear cell secretion of IFN-γ and that of the anti-inflammatory cytokine IL-10. These findings suggest a non-cytolytic modulation of inflammatory responses induced by the drug combination, that may be relevant in the pathophysiology of chronic HCV infection.
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Details
- Title
- EFFECTS OF THE RIBAVIRIN-INTERFERON α COMBINATION ON CULTURED PERIPHERAL BLOOD MONONUCLEAR CELLS FROM CHRONIC HEPATITIS C PATIENTS
- Creators
- Julio Martı́nJuan Antonio Quiroga - Hospital Universitario Fundación Jiménez DíazMargarita Pardo - Fundación para el Estudio de las Hepatitis ViralesSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Cytokine (Philadelphia, Pa.), v 10(8), pp 635-644
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000075284400010
- Scopus ID
- 2-s2.0-0010693314
- Other Identifier
- 991022047819704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology