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Accepted (AM)Open Access (License Unspecified), Open
Journal article
EMERGING APPLICATIONS OF ULTRASOUND-CONTRAST AGENTS IN RADIATION THERAPY
Ultrasound in medicine & biology, v 47(6), pp 1465-1474
01 Jun 2021
PMID: 33653626
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor cells and the vasculature. However, hypoxic regions in the tumor have been shown to not only decrease treatment response but also increase the likelihood of recurrence and metastasis. Ultrasound-sensitive micro-bubbles are emerging as a useful diagnostic and therapeutic tool within RT. Contrast-enhanced ultrasound (CEUS) has shown great promise in early prediction of tumor response to RT. Ultrasound-triggered micro-bubble cavitation has also been shown to induce bio-effects that can sensitize angiogenic tumor vessels to RT. Additionally, ultrasound can trigger the release of drugs from micro-bubble carriers via localized micro-bubble destruction. This approach has numerous applications in RT, including targeted oxygen delivery before radiotherapy. Furthermore, micro-bubbles can be used to locally create ROS without radiation. Sonodynamic therapy uses focused ultrasound and a sonosensitizer to selectively produce ROS in the tumor region and has been explored as a treatment option for cancer. This review summarizes emerging applications of ultrasound contrast agents in RT and ROS augmentation. (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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Details
- Title
- EMERGING APPLICATIONS OF ULTRASOUND-CONTRAST AGENTS IN RADIATION THERAPY
- Creators
- Quezia Lacerda - Thomas Jefferson UniversityMohamed Tantawi - Thomas Jefferson UniversityDennis B. Leeper - Thomas Jefferson UniversityMargaret A. Wheatley - Drexel UniversityJohn R. Eisenbrey - Thomas Jefferson University
- Publication Details
- Ultrasound in medicine & biology, v 47(6), pp 1465-1474
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- R01 EB26881; R01 CA238241 / United States National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000639165100002
- Scopus ID
- 2-s2.0-85101669298
- Other Identifier
- 991019169619404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging