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ERP based decision fusion for AD diagnosis across cohorts
Journal article   Open access

ERP based decision fusion for AD diagnosis across cohorts

Metin Ahiskali, Deborah Green, John Kounios, Christopher M Clark and Robi Polikar
Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), v 2009, pp 2494-2497
2009
PMID: 19965206
url
https://doi.org/10.1109/iembs.2009.5335141View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Alzheimer Disease - physiopathology Automation Reproducibility of Results Humans Evoked Potentials Alzheimer Disease - diagnosis Electrodes Algorithms Aged, 80 and over Brain - pathology Signal Processing, Computer-Assisted Early Diagnosis Cohort Studies
As the average life expectancy increases, particularly in developing countries, prevalence of neurodegenerative diseases has also increased. This trend is especially alarming for Alzheimer's disease (AD); as there is no cure to stop or reverse the effects of AD. However, recent pharmacological advances can slow the progression of AD, but only if AD is diagnosed at early stages. We have previously introduced an ensemble of classifiers based approach for combining event related potentials obtained from different electrode locations as an effective approach for early diagnosis of AD. We further expand this approach and analyze its robustness and stability in two ways: comparing the diagnostic accuracy on hand selected and cleaned data vs. standard automated preprocessing, but more importantly, comparing the diagnostic accuracy on two different cohorts, whose data are collected under different settings: a research university lab and a community clinic.

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Collaboration types
Domestic collaboration
Web of Science research areas
Engineering, Biomedical
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