Alzheimer Disease - physiopathology Automation Reproducibility of Results Humans Evoked Potentials Alzheimer Disease - diagnosis Electrodes Algorithms Aged, 80 and over Brain - pathology Signal Processing, Computer-Assisted Early Diagnosis Cohort Studies
As the average life expectancy increases, particularly in developing countries, prevalence of neurodegenerative diseases has also increased. This trend is especially alarming for Alzheimer's disease (AD); as there is no cure to stop or reverse the effects of AD. However, recent pharmacological advances can slow the progression of AD, but only if AD is diagnosed at early stages. We have previously introduced an ensemble of classifiers based approach for combining event related potentials obtained from different electrode locations as an effective approach for early diagnosis of AD. We further expand this approach and analyze its robustness and stability in two ways: comparing the diagnostic accuracy on hand selected and cleaned data vs. standard automated preprocessing, but more importantly, comparing the diagnostic accuracy on two different cohorts, whose data are collected under different settings: a research university lab and a community clinic.
ERP based decision fusion for AD diagnosis across cohorts
Creators
Metin Ahiskali -
Signal Processing and Pattern Recognition Laboratory, Department of Electrical and Computer Eng. at Rowan University, Glassboro, NJ 08028, USA. mahiskali@gmail.com
Deborah Green
John Kounios
Christopher M Clark
Robi Polikar
Publication Details
Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), v 2009, pp 2494-2497
Publisher
The Institute of Electrical and Electronics Engineers, Inc. (IEEE); United States
Grant note
AG10124 / NIA NIH HHS
AG022272 / NIA NIH HHS
Resource Type
Journal article
Language
English
Academic Unit
Psychological and Brain Sciences (Psychology)
Web of Science ID
WOS:000280543601361
Scopus ID
2-s2.0-77950982482
Other Identifier
9781424432967; 1424432960; 991014878209004721
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