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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants
American journal of perinatology, v 34(3), 240
01 Feb 2017
PMID: 27455401
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To determine whether reduced growth velocity (GV) in extremely low birth weight infants is preceded by elevated inflammatory cytokines.
Study Design GV was determined at 36 weeks' postrnenstrual age (PMA) in 768 infants 401 to 1,000 g birth weight (BW). Association between blood cytokines measured through day of life 21 and GV was explored using linear regression models that adjusted for late-onset sepsis (LOS), BW, small for gestational age (SGA), gender, race, energy intake, and center.
Results Serum interleukin-6 (IL-6) was increased at days 14 and 21 in LOS infants. LOS was associated with reduced energy intake and GV for weight (weight-GV) at 36 weeks' PMA. Linear regression analysis controlling for LOS and energy intake showed significant relationships between increased IL-6 at days 14 and 21 with reduced weight-GV at 36 weeks' PMA (p < 0.0001). The relationship between day 21 IL-6 and weight-GV was not associated with LOS (p = 0.12) when controlling for BW and energy intake. Both BW (p = 0.02) and energy intake (p = 0.003) influenced the relationship between day 14 IL-6 and weight-GV.
Conclusion IL-6 elevation during the first month of life is associated with lower weight-GV at 36 weeks' PMA and may have a direct effect upon energy balance and postnatal growth.
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Details
- Title
- Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants
- Creators
- Lee A. Denson - Cincinnati Children's Hospital Medical CenterScott A. McDonald - RTI InternationalAbhik Das - RTI InternationalDiana E. Schendel - National Center on Birth Defects and Developmental DisabilitiesKristin Skogstrand - Statens Serum InstitutDavid M. Hougaard - Statens Serum InstitutSeetha Shankaran - Wayne State UniversityRosemary D. Higgins - National Institute of Child Health and Human DevelopmentWaldemar A. Carlo - University of Alabama at BirminghamRichard A. Ehrenkranz - Yale New Haven HospitalCytokines Study Subcomm NICHD Neon
- Publication Details
- American journal of perinatology, v 34(3), 240
- Publisher
- Thieme Medical Publishers
- Number of pages
- 8
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA U10HD040492 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10HD040498 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Human Development (NICHD) Neonatal Research Network R01 DK058259 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) M01RR000080 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR001449 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) United States Public Health Service; United States Department of Health & Human Services National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DK068164 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000393724000006
- Scopus ID
- 2-s2.0-84979666321
- Other Identifier
- 991021229880104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics