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Journal article
Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis
Vaccines (Basel), v 6(3)
01 Sep 2018
PMID: 30103457
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance. These strategies include heightening T-cell response and vaccine induction of anti-cancer memory against tumor-associated antigens. Early investigations with chimeric antigen receptor T cells (CAR-T cells), vaccine-based therapies, dendritic cells (DCs) in combination with pro-inflammatory cytokines and natural killer cells (NKs), adoptive cell transfer, and immune checkpoint inhibitors represent significant advances in the treatment of PM. IP delivery of CAR-T cells has shown demonstrable suppression of tumors expressing carcinoembryonic antigen. This response was enhanced when IP injected CAR-T cells were combined with anti-PD-L1 or anti-Gr1. Similarly, CAR-T cells against folate receptor alpha expressing tumors improved T-cell tumor localization and survival when combined with CD137 co-stimulatory signaling. Moreover, IP immunotherapy with catumaxomab, a trifunctional antibody approved in Europe, targets epithelial cell adhesion molecule (EpCAM) and has shown considerable promise with control of malignant ascites. Herein, we discuss immunologic approaches under investigation for treatment of PM.
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Details
- Title
- Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis
- Creators
- Anusha Thadi - Drexel UniversityMarian Khalili - Drexel UniversityWilliam F. Morano - Drexel UniversityScott D. Richard - Thomas Jefferson University HospitalSteven C. Katz - Boston UniversityWilbur B. Bowne - Drexel University
- Publication Details
- Vaccines (Basel), v 6(3)
- Publisher
- Mdpi
- Number of pages
- 16
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:000443934000020
- Scopus ID
- 2-s2.0-85051843798
- Other Identifier
- 991019168009704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental