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Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates
Journal article   Open access   Peer reviewed

Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates

Carole Elbim, Valerie Monceaux, Yvonne M Mueller, Mark G Lewis, Stephanie François, Ousmane Diop, Khadija Akarid, Bruno Hurtrel, Marie-Anne Gougerot-Pocidalo, Yves Lévy, …
The Journal of immunology (1950), v 181(12), pp 8613-8623
15 Dec 2008
DOI: https://doi.org/10.4049/jimmunol.181.12.8613
PMID: 19050281
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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http://www.jimmunol.org/content/181/12/8613.full.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.4049/jimmunol.181.12.8613View
Published, Version of Record (VoR) Open

Abstract

Animals Apoptosis - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Disease Progression Longitudinal Studies Lymphopenia - immunology Lymphopenia - pathology Lymphopenia - virology Macaca mulatta - immunology Macaca mulatta - virology Monkey Diseases - immunology Monkey Diseases - pathology Monkey Diseases - virology Neutrophil Infiltration - immunology Neutrophils - immunology Neutrophils - pathology Neutrophils - virology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - pathology Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - pathogenicity Species Specificity Time Factors
We used pathogenic and nonpathogenic simian models of SIV infection of Chinese and Indian rhesus macaque (RMs) and African green monkeys (AGMs), respectively, to investigate the relationship between polymorphonuclear neutrophil (PMN) death and the extent of viral replication and disease outcome. In this study, we showed that PMN death increased early during the acute phase of SIV infection in Chinese RMs and coincided with the peak of viral replication on day 14. The level of PMN death was significantly more severe in RMs that progressed more rapidly to AIDS and coincided with neutropenia. Neutropenia was also observed in Indian RMs and was higher in non-Mamu-A*01 compared with Mamu-A*01 animals. In stark contrast, no changes in the levels of PMN death were observed in the nonpathogenic model of SIVagm-sab (sabaeus) infection of AGMs despite similarly high viral replication. PMN death was a Bax and Bak-independent mitochondrial insult, which is prevented by inhibiting calpain activation but not caspases. We found that BOB/GPR15, a SIV coreceptor, is expressed on the PMN surface of RMs at a much higher levels than AGMs and its ligation induced PMN death, suggesting that SIV particle binding to the cell surface is sufficient to induce PMN death. Taken together, our results suggest that species-specific differences in BOB/GPR15 receptor expression on PMN can lead to increased acute phase PMN death. This may account for the decline in PMN numbers that occurs during primary SIV infection in pathogenic SIV infection and may have important implications for subsequent viral replication and disease progression.

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Immunology
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