Journal article
Early effects of right latissimus dorsi cardiomyoplasty on left ventricular function
Circulation (New York, N.Y.), v 88(5 Pt 2), pp II298-II303
01 Nov 1993
PMID: 8222169
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUNDWe hypothesized that left ventricular function could be improved with cardiomyoplasty using the right latissimus dorsi.METHODS AND RESULTSFive dogs underwent cardiomyoplasty using the right latissimus dorsi. Left ventricular volume and pressure were measured using sonomicrometry and a micromanometer catheter, respectively. Pressure volume loops were recorded with the muscle stimulated at 1:2 and with transient caval occlusion. During stimulated beats, there were significant increases in stroke work (13.90 +/- 4.49 vs 9.78 +/- 3.81 g/m, P < .01), preload recruitable stroke work (0.766 +/- 0.110 vs 0.594 +/- 0.207 g.m-1 x m-3, P < .05), and stroke volume (15 +/- 4 vs 10 +/- 3 mL, P < .05) when compared with unstimulated beats. There were no changes in diastolic filling. This operation was done in 11 patients, with no operative deaths. Six weeks after surgery, resting left ventricular ejection fraction (LVEF) increased from 25 +/- 1.6% to 35 +/- 3% (P < .05), and left ventricular end-diastolic volume (LVEDV) decreased from 365 +/- 18 to 307 +/- 24 mL, (P < .05). Nine patients were alive at 6 months. Preoperative and 6-month LVEF and LVEDV for those 9 patients were 26 +/- 2% and 29 +/- 2% (P = NS) and 316 +/- 23 and 261 +/- 22 mL (P < .05), respectively.CONCLUSIONSLong-term studies are needed to determine if these changes will improve patient survival.
Metrics
3 Record Views
Details
- Title
- Early effects of right latissimus dorsi cardiomyoplasty on left ventricular function
- Creators
- J A MagovernS E ParkB L CmolikD R TrumbleI Y ChristliebG J Magovern
- Publication Details
- Circulation (New York, N.Y.), v 88(5 Pt 2), pp II298-II303
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:A1993ME83400042
- Scopus ID
- 2-s2.0-0027489826
- Other Identifier
- 991019184205904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease