Journal article
Early embryo loss is associated with the prior expression of macrophage activation markers in the decidual
The Journal of immunology (1950), v 158(10), pp 4886-4892
15 May 1997
PMID: 9144505
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In early embryo loss, the activation of maternal immune effector mechanisms play a critical role in determining the success or failure of a pregnancy. We have previously shown that increased nitric oxide production by decidual macrophages is involved in early embryo loss occurring at day 12 of gestation. In this study, using reverse transcription-PCR and Southern blotting, the expression of inducible nitric oxide synthases (iNOS) and TNF-alpha mRNA was determined to quantify macrophage activation in individual murine embryos in a model of spontaneous early embryo loss. At day 8 of gestation, 32 and 29% of embryos with no apparent pathology showed an increase in iNOS and TNF-a mRNA expression, respectively. This corresponds to the natural resorption rate seen in the mouse model. In addition, the percentage of embryos with increased iNOS and TNF-alpha mRNA expression was further augmented when pregnant mice were induced to abort at a higher rate. These results showed, for the first time, a correlation between increased iNOS and TNF-alpha expression and embryo resorption. The results provide evidence for the presence of activated macrophages at implantation sites before overt embryo damage occurs.
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Details
- Title
- Early embryo loss is associated with the prior expression of macrophage activation markers in the decidual
- Creators
- E K HaddadA J DuclosW S LappM G Baines
- Publication Details
- The Journal of immunology (1950), v 158(10), pp 4886-4892
- Publisher
- American Association of Immunologists
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:A1997WX98700045
- Scopus ID
- 2-s2.0-0031570095
- Other Identifier
- 991020111160004721
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- Web of Science research areas
- Immunology