Journal article
Early lead exposure and childhood adiposity in Mexico city
International journal of hygiene and environmental health, v 222(6), pp 965-970
01 Jul 2019
PMID: 31257186
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Prenatal and early childhood lead exposures have been associated with reduced weight in infants and young children, while studies that have examined such associations in children during peripubescence are rare.
Objectives: We investigated the associations of prenatal and early-life exposure to lead with indices of adiposity in peripubertal children living in Mexico City.
Methods: Maternal bone lead (as a proxy for cumulative fetal exposure) was assessed at 1 month postpartum. Blood samples were obtained from children annually from 1 to 4 years. Multivariable linear regression models were used to examine the association between each lead biomarker and BMI z-score, waist circumference, sum of skinfolds and body fat percentage in 248 children aged 8-16 years.
Results: After adjusting for covariates, maternal patella lead was associated with lower child BMI z-score (beta = - 0.02, 95% CI: 0.03, - 0.01, p = 0.004), waist circumference (beta = - 0.12 cm, 95% CI: 0.22, - 0.03, p = 0.01), sum of skinfolds (beta = - 0.29 mm, 95% CI: 0.50, - 0.08, p = 0.007) and body fat percentage (beta = - 0.09%, 95% CI: 0.17, -0.01, p = 0.03). No significant associations were detected from the postnatal exposure period.
Conclusions: We observed a significant and inverse association of prenatal lead exposure with body composition in Mexican children, suggesting the potential role of early lead exposure in the fetal programming of child growth. Further research on the biological mechanisms underlying these associations is needed.
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Details
- Title
- Early lead exposure and childhood adiposity in Mexico city
- Creators
- Yun Liu - University of MichiganKaren E. Peterson - University of MichiganKathleen Montgomery - University of MichiganBrisa N. Sanchez - University of MichiganZhenzhen Zhang - University of MichiganMyriam C. Afeiche - Nestlé (United States)David E. Cantonwine - Brigham and Women's HospitalAdrienne S. Ettinger - University of MichiganAlejandra Cantoral - Instituto Nacional de Salud PúblicaLourdes Schnaas - Instituto Nacional de Salud PúblicaHoward Hu - University of WashingtonMartha M. Te'llez-Rojo - Inst Nacl Salud Publ, Ctr Invest Nutr & Salud, Cuernavaca, Morelos, Mexico
- Publication Details
- International journal of hygiene and environmental health, v 222(6), pp 965-970
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- P20ES018171/RD834800 / U.S. National Institute of Environmental Health Sciences (NIEHS)/the U.S. Environmental Protection Agency (EPA) R01ES007821 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000516828300006
- Scopus ID
- 2-s2.0-85067977310
- Other Identifier
- 991020100211504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases
- Public, Environmental & Occupational Health